The key difference there, I think, is that in Pettine’s defense I would expect to see a lot of sub (specifically nickel) that still features three true defensive linemen.
I would not be surprised to see it, but I would be very surpirsed to see it "a lot". This assumes one of two things:
1) You're pulled Perry or Matthews (or Gilbert if one of those guys is injured) off the field, in what amounts to a 4-3 hybrid line with a stand-up elephant in Perry or Matthews while retaining 2 ILBs. Is that the optimal pass rush combination at this stage of Wilkerson's career? Please do not tell me that this configuration will be played "a lot" with Matthews at ILB. There's an assumption here that Wilkerson will return to his double-digit sack glory of 2013 or 2015 which, one should be reminded, were after Pettine moved on to the Buffalo head coaching job. You do not have your best edge rushers on the field in this configuration.
2) Alternatively, one supposes, it could be a 3-man front with Perry and Matthews on the edge, essentially a 3-4 base front, with one ILB and 5 DBs. That ain't gonna work, being highly vulnerable to the run and passes to and across the short middle that NFL offesnes like so much these days and which gave rise to the hybrid ILB. Now. you could bring a safety up into the box, but now he's in hybrid mode and you're back to a base configuration. That's where I would expect Wilkerson to get his primary snaps...in base.
Your proposal only makes sense if:
1) Wilkerson is more productive rushing the passer at what amounts to a 4-3 DE position (5-tech or wide 5 on the weak side, 6 tech over the TE on the strong side) that what you'd get out of Perry or Matthews. There's no way he plays true edge at 9 tech.
or
2) He's as productive as Peppers justifying a 3-man edge rotation with varying looks. Wilkerson might have been that guy a few years ago. I'm not seeing it now. Maybe he'll surprise me.
or
3) Your best bet is if Perry or Matthews in injured and Gilbert doesn't flash under the bright lights against first teamers. But getting back to Navarro, which is where this started, that's one of the reasons you'd want him, or somebody else with similar characteristics...injury backup.
But this disucssion was about Navarro with Wilkerson's role as a point of comparison. I don't propose paying him even Wilkerson money.