Lukas Van Ness, ED/DL, Iowa:
-6'5" 272#
-4.58 w/ 1.57 split
-4.32/7.02 agilities
Myles Murphy, ED, Clemson:
-6'5" 268#
-4.53 w/1.59 split
-4.29/ 7.21 agilities
These guys are so rare that if you go looking for players who ran sub 4.6 and were sub 4.35/7.30 in the agilities at 265+, you almost can't find guys. The ones who actually hit those are in bold below.
The rest are the closest athletic comps otherwise that I can find in recent combine history (i.e. post 2010):
-Trey Hendrickson, FAU, 2017: 6'4", 266#, 4.65, 4.40, 7.03
-Jadeveon Clowney, SC, 2014: 6'5", 266#, 4.53, 4.43, 7.27
-Owamagba Odighizuwa, UCLA, 2015: 6'4", 267#, 4.62, 4.19, 7.36
-Bradley Chubb, NCSU, 2018: 6'4", 269#, 4.65, 4.41, 7.37
-Bud Dupree, Kentucky, 2015: 6'4", 269#, 4.56, 4.48, 7.52
-Ezekiel Ansah, BYU, 2013: 6'5", 271#, 4.63, 4.26, 7.11
-Nick Perry, USC, 2012: 6'5", 271#, 4.55, 4.66, 7.25
-Travon Walker, UGA, 2022: 6'5", 272#, 4.51, 4.32, 6.89
-Myles Garrett, TAMU, 2014: 6'4", 272#, 4.64, 4.20, N/A
-Emmanuel Ogbah, MIZZ, 2016: 6'4", 273#, 4.63, 4.50, 7.26
-Everson Griffen, USC, 2010: 6'3", 273#, 4.65, 4.36, 7.25
-Carlos Basham, WF, 2021: 6'3", 274#, 4.62, 4.32, 7.13
-Rashan Gary, MICH, 2019: 6'4", 277#, 4.58, 4.29, 7.26
-Carlo Dunlap, FLA, 2010: 6'6", 278#, 4.68, 4.61, 7.21
-DaQuan Bowers, CLEM, 2011: 6'3", 280#, 6.64, 4.57, 6.98
We throw around the term "freak" in the pre-draft process a lot. It's annoying, because a "freak" should rightly refer to someone who is so athletic that you almost never see comparable guys. The term actually applies to Van Ness and Murphy. These are rare, rare athletes, and they're both young and still developing. As you can see, guys like this almost never bust. Even when they aren't homeruns, they're high floor players who return a lot of value. And when they really hit, they're some of the most valuable players in the league.