Biggest variable right now is whether Hurts clears the concussion protocol. Second biggest is if Walker gets healthy and the Packers put him in for snaps over Cooper...Cooper is playing like a first round LB while Walker has, over his entire career, played like cornerback who can't cover (i.e., he can't take on blocks, can't cover, and consistently makes tackles 5+ yards downfield).
Packers defense (assuming coaches are smart and keep Cooper on the field over Walker) should be able to hold up pretty well against an Eagles offense minus Hurts...if Hurts plays then things might get rough because the defense's Achilles heel all season has been an absolutely awful pass rush. If the Packers can't get any pressure on Hurts he'll have all day to wait until Brown or Smith get open against a surprisingly adequate coverage group. Also, the Eagles have a TERRIFIC oline and, coupled with a bad Packers dline and Barkley, I'm certainly worried about the defense holding up if it's a close game in the 4th.
Packers offense on the other hand...I'm worried about that. When Watson is on the field, the Packers offense is elite, like top-5 elite. When he's out, the offense is mediocre. He provides so much to offense in his ability to run block and his ability to stretch the field. Without Watson, the Eagles will just sit on everything and make it really hard to do anything on offense. I would like to say I trust MLF to overcome that but I'm not sure that's possible for any coach with an offense that will be constipated by a lack of a real deep threat against the best defense in the NFL.