I expect SF to be over aggressive the first couple of drives. Lots of loaded boxes and sending extra rushers all in trying to create disruption early to get some momentum and quiet the crowd. That’s what worked in Dallas, SF literally hushed the crowd for 3.5 quarters.
I’d get the ball out quicker and decisively for some 5 yard chunks and keep their D on the field with a slow methodical bleeding. At some juncture we will need to test our Run game. If Dillon can rush for 6 yards a carry against Tampa last season, he should be good for 4-5 yards a carry in bulk. Wear them down early with a humiliating 75 yard, 7 minute drive.