I'm going to throw out another game. The 2001 playoff loss to the Rams. Ahman Green had rushed for almost 1,400 yards that season, the defense was great (3rd least points allowed in team history, broke record for most sacks in a season with 52), and we had just beaten the 49ers in the wildcard round - payback for the 1999 Terrell Owens let down. With Brett Favre leaning on a powerful running game and strong defense, we shouldn't need to sling the ball around with reckless abandon...
Then Favre throws six interceptions, including three pick-6s en route to a 17-45 loss. That was one of my least favorite moments.